The Bioprocess Scale-Up Facility was created in 1985 to help Maryland companies, as well as university and federal researchers, scale-up biotechnology products efficiently and inexpensively.
The BSF would later be expanded to include yearly workshops on Fermentation, Downstream Processing and Cell Culture, as well as customized trainings for companies such as MedImmune.
A second facility dedicated to Cell Culture technologies was opened in Shady Grove in 2010. The expanded focus prompted a rename to the Biotechnology Research and Education Program (BREP), which included the Bioprocessing Scale-Up Facility (BSF) in College Park, and the Biopharmaceutical Advancement Facility (BAF) in Shady Grove.
More than 125 students and employees worked in BREP during its 35-year history. The program was closed in 2020.